Development of a green synthesis process for ibuprofen based on continuous flow chemistry technology
基于连续流化学技术的布洛芬绿色合成工艺开发

摘要

布洛芬作为常用非甾体抗炎药，市场需求庞大。传统合成工艺存在步骤繁琐、副反应多、原料利用率低及污染重等问题。连续流化学技术凭借高效传质传热、精准控温及连续化生产优势，为其绿色合成带来突破。本研究运用微通道反应器，优化傅克酰化、缩酮化等关键步骤，通过调控浓度、温度等参数，提升反应效率与选择性，降低能耗与排放，该工艺兼具经济与环境效益，工业应用前景广阔。

Abstract

Ibuprofen, a commonly used non-steroidalanti-inflammatory drug (NSAID), has a huge market demand. Traditional synthesis methods are characterized by complex procedures, numerous side reactions, low raw material utilization, and significant pollution. Continuous flow chemistry technology, with its advantages of efficient mass and heat transfer, precise temperature control, and continuous production, has made a breakthrough in the green synthesis of ibuprofen. This study employs microchannel reactors to optimize key steps such as Friedel-Crafts acylation and acetalization. By adjusting parameters like concentration and temperature, the process enhances reaction efficiency and selectivity while reducing energy consumption and emissions. This process offers both economic and environmental benefits and has broad industrial application potential.